Advanced Intestinal Barrier
Why it Matters
Your gut lining plays a crucial role in overall health, acting as a protective barrier that regulates nutrient absorption and prevents harmful substances from entering the bloodstream. When this barrier is compromised—a condition known as intestinal permeability or "leaky gut"—it can trigger widespread inflammation, immune dysfunction, and chronic health issues.
The Advanced Intestinal Barrier Assessment is a comprehensive test that evaluates gut permeability and mucosal integrity. It measures key biomarkers associated with intestinal lining damage, immune activation, and microbial imbalance, offering valuable insights into gut-related symptoms.
At Goode Health, we often see gut dysfunction contributing to burnout, chronic fatigue, autoimmune diseases, skin conditions, and mood disorders. This test helps pinpoint underlying issues such as increased permeability, immune reactivity, and digestive stress—allowing for a targeted, evidence-based plan to support gut healing, reduce inflammation, and restore optimal health.
If you struggle with digestive discomfort, food sensitivities, brain fog, fatigue, or unexplained inflammation, this test may provide the missing answers to your health concerns.
Markers
DAO: Histamine Ratio – Assesses the balance between histamine and diamine oxidase (DAO), crucial for histamine breakdown.
Diamine Oxidase (DAO) – An enzyme responsible for histamine degradation; low levels may indicate histamine intolerance.
Histamine – Elevated levels can contribute to inflammation, digestive issues, and immune dysregulation.
Lipopolysaccharide (LPS) IgA, IgG, IgM – Detect immune responses to bacterial endotoxins, which can indicate leaky gut and systemic inflammation.
Zonulin – A key regulator of tight junctions in the gut; elevated levels suggest increased intestinal permeability.
Who should consider this test
✔ Digestive Issues – Persistent bloating, diarrhoea, constipation, or abdominal pain.
✔ Histamine Intolerance Symptoms – Flushing, headaches, itching, sinus congestion, or food sensitivities.
✔ Leaky Gut & Autoimmune Conditions – Conditions such as IBS, Crohn’s disease, rheumatoid arthritis, or thyroid disorders.
✔ Chronic Inflammation & Fatigue – Unexplained fatigue, joint pain, or brain fog.
✔ Frequent Infections & Allergies – Increased susceptibility to infections, seasonal allergies, or skin conditions like eczema.
✔ Food Sensitivities – Reactions to certain foods, including skin issues, digestive discomfort, and inflammation.
✔ Cognitive Decline – Memory issues, difficulty concentrating, or neuroinflammation-related concerns.
Price £355
You will require a blood draw this can be booked to be done at your home. This is an additional cost. We will send you phlebotomists based in your area for you to arrange. National average is approx £45